The QX60 was redesigned for the 2022 model year. The cabin has a modern look, while adding rich leather and modern controls. Through 2024, the QX60 shared the 295-hp, 3.5-liter V6 engine paired with a nine-speed automatic transmission with the redesigned Nissan Pathfinder. For the 2025 model year, the V6 engine was replaced with a 2.0-liter turbo four-cylilnder. Front- and all-wheel drive are available.
A standard 12.3-inch touch screen, mounted prominently on top of the center dash, has an elegant, integrated look. Many functions are handled via the screen or steering wheel controls. Seven-passenger seating is standard. The one-touch controls tilt and slide the outboard second-row seats forward, providing a path to the third-row seats, which Infiniti claims are roomier than in the previous generation. Standard active safety systems include FCW, AEB with pedestrian detection, LDW, and BSW. The ProPilot Assist system, which is standard on all but the Pure trim, uses adaptive cruise control and steering assistance to keep the QX60 within the lane markings while driving.