The Mercedes-Benz E350 is a delight to drive. It feels reassuringly solid and offers an inviting blend of luxury and practicality. The E350 provides excellent ride comfort and agile handling, along with a beautifully constructed and roomy interior featuring supportive seats as well as good outward visibility. Still though, we found some controls to be overly complicated.
The E320 diesel (which we also tested) delivers very good performance as well. There is little diesel smell and the engine is very quiet. While it has plenty of midrange torque, the diesel isn't as quick the gasoline engine. Fuel economy for the diesel, however, is much better. It manages an impressive 29 mpg overall.